NUPLAZID® is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.
Hallucinations and delusions
are a treatable part of
Parkinson’s disease
Hear from real people taking NUPLAZID
If you think you or your loved one may be experiencing PD-related hallucinations and delusions, talk to your doctor about a treatment option. Our Treatment Discussion Guide can help you prepare for the discussion.
These stories represent the experiences of people living with PD-related hallucinations and delusions. The opinions expressed are their own, and individual experiences may vary. Always speak with your healthcare provider.
Beverly & Bud’s story
Six years after being diagnosed with PD, Beverly started to experience hallucinations and delusions related to her Parkinson's. In this video, Beverly and her husband, Bud, share their story—from the first signs of Beverly’s symptoms to treatment with NUPLAZID.
John’s story
John is affected by hallucinations and delusions associated with PD psychosis. In this video, John speaks about the impact they have had on him, and his experience taking NUPLAZID to treat these symptoms.
Find out more about treatment with NUPLAZID
How NUPLAZID can help
NUPLAZID reduced the frequency and/or severity of Parkinson's disease
(PD)–related hallucinations and delusions
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In the clinical trial, the majority of patients who took NUPLAZID experienced fewer and/or less severe hallucinations and delusions associated with PD psychosis when compared to placebo
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Some patients did not experience any hallucinations or delusions at 6 weeks. Not everyone will respond to NUPLAZID. Individual results may vary
The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.
NUPLAZID had no effect on motor symptoms
- In the clinical trial, NUPLAZID had no effect on motor symptoms compared with a placebo at 6 weeks
Clinical trial details
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To test the efficacy of NUPLAZID, an FDA-accepted tool measured the changes in the frequency and/or severity of hallucinations and delusions associated with PD psychosis
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The clinical trial included 199 adults (at least 40 years of age with an average age of 72 years) diagnosed with hallucinations and delusions associated with PD psychosis that was severe and frequent enough for treatment
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Each person was assigned to 1 of 2 groups: those who received NUPLAZID 34 mg or those who received placebo. Results were reported at the end of 6 weeks
Dosing information for NUPLAZID
NUPLAZID works around-the-clock to help reduce hallucinations and delusions associated with PD psychosis
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The recommended dose of NUPLAZID is one 34 mg capsule, once daily by mouth, with or without food, around the same time every day, or as prescribed by your healthcare provider
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It’s important to remember that everyone responds to medications differently, so it may take some time for NUPLAZID to start working
Continuing to take NUPLAZID as prescribed may help you see results
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NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect
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You should speak with your healthcare provider before you stop taking NUPLAZID
NUPLAZID and other medications
Taking NUPLAZID
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You can take NUPLAZID without adjusting doses of carbidopa/levodopa medicines
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NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval
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Tell your healthcare provider about any changes in the medicines you are taking. Some prescriptions or over-the-counter medicines may interact with NUPLAZID and should not be taken
Important Safety Information
Who should not take NUPLAZID?
- Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
- Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.
What other warnings should I know about NUPLAZID?
- QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.
See below for additional Important Safety Information.
Have questions about your treatment options? Bring the Treatment Discussion Guide to your next appointment
Get more information about PD-related hallucinations and delusions
IMPORTANT SAFETY INFORMATION and INDICATION
What is the most important information I should know about NUPLAZID?
Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).
NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.
Who should not take NUPLAZID?
- Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
- Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.
What other warnings should I know about NUPLAZID?
- QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.
Please also see What is the most important information I should know about NUPLAZID?
What medicine might interact with NUPLAZID?
- Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.
What are the common side effects of NUPLAZID?
- The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).
Indication
NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.
How should I take NUPLAZID?
The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth, with or without food.
NUPLAZID is available as 34 mg capsules and 10 mg tablets.
Please read the full Prescribing Information, including Boxed WARNING.